Department of Cognitive Neuroscience · Maastricht University
Cognitive Computational Neuroscience Group
Research
What we study
The group asks which features of biological organization matter for function, meaning what the brain can do and how it does it. We approach this question from two directions.
From the side of biology, we build biophysics-informed deep learning models and functional whole-brain models. In these models, features of biological structure can be imposed, varied or removed. The features range from retinal sampling and cortical layers and columns to large-scale connectivity. Each manipulation shows what a feature contributes to what the model can do.
From the side of function, we train models to perform tasks and then ask how much they come to resemble the brain. AngoraPy, our toolbox for goal-driven training of brain-inspired models, and our neural network model of dexterous hand control take this route.
We compare models with human behaviour and neural dynamics. Where their predictions call for it, we run psychophysical experiments. Our work spans visual content that is presented externally and content that is generated internally. Applications include how the visual system adapts to and recovers from disorders such as glaucoma, and face perception in forensic settings such as identifying AI-enhanced imagery.
News
Latest
Oct 2026
Tamar Couprie joins the group as a PhD candidate. Her project False Clarity is an FPN Strategic Research Plan interdisciplinary PhD project.
29 Sep 2026
Mario speaks at the Bernstein Conference workshop Reconciling biology and function in large-scale brain models in Frankfurt. The talk is titled Reconciling Biology and Function via Biophysics-Informed Deep Learning.
16 Sep 2026
OHBM Neurosalience releases its season 6 finale (S6E15). It is a live-audience panel recorded at OHBM 2026 in Bordeaux. Peter Bandettini hosts Satrajit Ghosh, Giulia Baracchini, Vince Calhoun and Mario.
Collaborators
Who we work with
- Birke BenedikterOphthalmology, University Eye Clinic MaastrichtMaastricht UMC+From Blind Spots to Brain Plasticity, a CIN project on glaucoma with Matthijs KustersVisit website
- Peter De WeerdPerception, Department of Cognitive NeuroscienceMaastricht UniversityVisit website
- Gustavo DecoComputational Neuroscience GroupUniversitat Pompeu Fabra, BarcelonaVisit website
- Marcel van GervenArtificial Cognitive Systems lab, Donders InstituteRadboud UniversityDigital brain twins, funded by the Maastricht-Radboud Joint Collaboration Fund, with Nicole RogallaVisit website
- Satrajit GhoshSenseable Intelligence Group, McGovern InstituteMassachusetts Institute of TechnologyVisit website
- Matthieu GilsonBraiNets, Institut de Neurosciences de la TimoneAix-Marseille UniversitéVisit website
- Rainer GoebelDepartment of Cognitive NeuroscienceMaastricht UniversityPromotor of Dasja de LeeuwVisit website
- Xenia KobelevaComputational Neurology GroupRuhr University BochumVisit website
- Jan KurzawskiDepartment of Cognitive NeuroscienceMaastricht UniversityNow You See It, Now You Don't, an NWO XS project on metamersVisit website
- Anna SaganaForensic Psychology, Clinical Psychological ScienceMaastricht UniversityFalse Clarity, with Tamar CouprieVisit website
- Gorka Zamora-LópezCenter for Brain and CognitionUniversitat Pompeu Fabra, BarcelonaVisit website
Contact
Get in touch
For the possibility of internships or lab visits, please contact Mario Senden via mario.senden@maastrichtuniversity.nl
Address
Department of Cognitive NeuroscienceFaculty of Psychology and Neuroscience
Maastricht University
Oxfordlaan 55
6229EV Maastricht
Elsewhere




