Contact

Contact

For the possibility of internships or lab visits, please contact Mario Senden via mario.senden@maastrichtuniversity.nl


Curriculum vitae


Department of Cognitive Neuroscience

Maastricht University

Oxfordlaan 55
6229EV Maastricht





Department of Cognitive Neuroscience

Maastricht University

Oxfordlaan 55
6229EV Maastricht



The global communication architecture of the human brain transcends the subcortical - cortical - cerebellar subdivisions


Journal article


Julian Schulte, M. Senden, G. Deco, X. Kobeleva, G. Zamora-López
bioRxiv, 2023

Semantic Scholar DOI
Cite

Cite

APA   Click to copy
Schulte, J., Senden, M., Deco, G., Kobeleva, X., & Zamora-López, G. (2023). The global communication architecture of the human brain transcends the subcortical - cortical - cerebellar subdivisions. BioRxiv.


Chicago/Turabian   Click to copy
Schulte, Julian, M. Senden, G. Deco, X. Kobeleva, and G. Zamora-López. “The Global Communication Architecture of the Human Brain Transcends the Subcortical - Cortical - Cerebellar Subdivisions.” bioRxiv (2023).


MLA   Click to copy
Schulte, Julian, et al. “The Global Communication Architecture of the Human Brain Transcends the Subcortical - Cortical - Cerebellar Subdivisions.” BioRxiv, 2023.


BibTeX   Click to copy

@article{julian2023a,
  title = {The global communication architecture of the human brain transcends the subcortical - cortical - cerebellar subdivisions},
  year = {2023},
  journal = {bioRxiv},
  author = {Schulte, Julian and Senden, M. and Deco, G. and Kobeleva, X. and Zamora-López, G.}
}

Abstract

The white matter is made of anatomical fibres that constitute the highway of long-range connections between different parts of the brain. This network is referred to as the brain’s structural connectivity and lays the foundation of network interaction between brain areas. When analysing the architectural principles of this global network most studies have mainly focused on cortico-cortical and partly on cortico-subcortical connections. Here we show, for the first time, how the integrated cortical, subcortical, and cerebellar brain areas shape the structural architecture of the whole brain. We find that dense clusters vertically transverse cortical, subcortical, and cerebellar brain areas, which are themselves centralised by a global rich-club consisting similarly of cortical and subcortical brain areas. Notably, the most prominent hubs can be found in subcortical brain regions, and their targeted in-silico lesions proved to be most harmful for global signal propagation. Individually, the cortical, subcortical, and cerebellar sub-networks manifest distinct network features despite some similarities, which underline their unique structural fingerprints. Our results, exposing the heterogeneity of internal organisation across cortex, subcortex, and cerebellum, and the crucial role of the subcortex for the integration of the global anatomical pathways, highlight the need to overcome the prevalent cortex-centric focus towards a global consideration of the structural connectivity.


Share



Follow this website


You need to create an Owlstown account to follow this website.


Sign up

Already an Owlstown member?

Log in